Application of biorelevant dissolution tests to the prediction of in vivo performance
Pharmaceutical Sciences Journals : Application of biorelevant dissolution tests to the prediction of in vivo performance of diclofenac sodium from an oral modified-release pellet dosage form. In vitro biorelevant dissolution tests enabling the prediction of in vivo performance of an oral modifiedrelease (MR) dosage formwere developed in this study. In vitro dissolution ofMRdiclofenac sodium pellets containing 100mg active ingredient was evaluated under simulated pre- and postprandial conditions using USP Apparatus 3 (reciprocating cylinder, Bio-Dis) and 4 (flow-through cell) and results compared with compendial methods using USP Apparatus 1 (basket) and 2 (paddle).
Download Journal pdf:
http://www.eurand.com/pdf/EURX_Papers_Apr_2009.pdf
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