Comparison of the Virulence Factors and Analysis of Hypothetical Sequences
Computer Science & Systems Biology Journal: Comparison of the Virulence Factors and Analysis of Hypothetical Sequences of the Strains TIGR4, D39, G54 and R6 of Streptococcus Pneumoniae.
Whole genome sequences of the four strains of Streptococcus pneumoniae, encapsulated TIGR4, D39, G54 and nonencapsulated R6 are considered for the comparative study on genome features, whole genome pairwise alignment, gene role category, and virulence factors using relevant comparative genomics tools. The study of capsular polysaccharide synthesizing genes reveals that many cps genes are unique to TIGR4, which shows the high virulence nature of TIGR4. Further, the study on the other virulence factors such as pneumococcal surface protein A, autolysin, hyaluronate lyase, pneumolysin, neuraminidase B, and pneumococcal surface antigen A of TIGR4 are much related to those of the other three strains, and hence the virulence nature due to these factors among four strains seems to be similar.
The whole genome pairwise alignments of the strains TIGR4, D39 and R6 of S. pneumoniae (whose sequence data are available at NCBI) are obtained using the standalone version of MUMmer and the results are plotted using its built-in mummerplot.
Comparative genomics and in silico studies have begun to reveal insights into gene and protein functions of many organisms. Results and Discussion: Comparison of Capsular Polysaccharide Synthesizing Genes , Comparison of the Role Category of Genes , Comparison of Virulence Factors Other than Capsular Polysaccharide Synthesizing Genes , Functional Annotation of Hypothetical Sequences Relevant to the Virulence Factors.
Download Journal pdf:
http://www.omicsonline.com/ArchiveJCSB/2008/December/01/JCSB1.103.pdf
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